Home > Imaging

Imaging platform

We are focusing our research on the bone and joint field, with a strong relationship with clinical research.

Our imaging methods help us to develop biomarkers. These markers are quantitative tools with the objective to follow structural variations in pathological and normal bone and joint tissues. One of the medical imaging apparatus used in our laboratory is the scanner (CT-scanner). This tool is using X-rays that are electromagnetic radiations composed with high energy photons being used in medical research for diagnostic purposes.

XtremCT Scanco

Peripheral Quantitative Tomography using X-rays to study the micro-architectural bone: high-resolution 3-D imaging (80µm3) of human bones (Radius and Tibia) for the diagnostic and the follow-up of osteoporosis disease.

On the left, patient with an idiopathic osteoporosis (decrease number and thinning of trabeculae), on the right, healthy patient (numerous and well connected trabeculae)

Measured paramaters

Plateforme collaborative SFR IMOSAR www.imosar.fr

Micro-scanner in vitro Skyscan 1272

Descriptive : High-resolution 3-D imaging (5 to 30 µm3) with X-rays in animal or human tissues with or without integrated biological material.

Measured paramaters (examples)

Study of vertebral or femoral bone microarchitecture

Femurs of mices : Up level = 3D images, down level = 2D slices

Arthritis and arthrosis study

We can measure bone density and eroded joints of lower limbs of mices with arthritis (inflammation) and/or mecanical arthrosis.
arthritis study : Paws of mices (without arthritis and with arthritis (=CIA))

At cartilage knee level, we are setting up analysis methods of calcified and non-calcified areas.

Knee of female hfe mouse
External plate
internal plate

Lunar PIXImus
Descriptive : The Lunar PIXImus Densitometer (GE Medical Systems) provides in vivo bone mineral density and body composition results from total body imaging (lean and fat mass) of little animal such as mice. It is based on low x-ray energy. It allows the researcher the opportunity to make multiple measurements in situ during the life of the animal, providing true longitudinal measures.

Measured Parameters :

Bone mineral density.
Total body composition (% of lean and fat mass).

Stratec XCT Research SA+

Descriptive : Peripheral quantitative computed tomograph for the evaluation of volumetric bone density and muscle parameter at small laboratory animals like mice and rats, in vivo and ex-vivo.

Measured Parameters:

Plateforme collaborative SFR IMOSAR www.imosar.fr